FBXO38

Across TCGA patient cohorts, FBXO38 mutation is significantly associated with the RNA expression of many other genes, with 4,522 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO38-associated genes across cancer lineages are CDT1, TSEN34, and SAMM50. Each is linked with FBXO38 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXO38-to-partner and partner-to-FBXO38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDT1 grouped by FBXO38-low versus FBXO38-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO38→partner) and Y-score (partner→FBXO38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDT1 →	+0.716	+2.082	<.001	<.001	3	3
SKCM	TSEN34 →	+0.457	+2.597	<.001	.005	3	3
UCEC	SAMM50 →	+0.356	+1.828	.004	<.001	3	3
UCEC	TOMM40 →	+0.304	+2.061	.007	<.001	3	3
UCEC	GINS2 →	+0.705	+1.850	<.001	<.001	3	3
UCEC	CALM3 →	+0.336	+1.399	.007	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,522 associations by consensus.

CDT1 by FBXO38 expression — UCEC

Explore this box plot interactively →