FBXO36

Across TCGA patient cohorts, FBXO36 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO36-associated genes across cancer lineages are MEK1, PCNA, and p38-MAPK_pT180_Y182. Each is linked with FBXO36 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO36-to-partner and partner-to-FBXO36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by FBXO36-low versus FBXO36-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO36→partner) and Y-score (partner→FBXO36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.445	+3.169	.026	.019	3	1
UCEC	PCNA →	+0.282	+3.169	.017	.020	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.487	-3.156	.048	.020	2	1
UCEC	FoxM1 →	+0.296	+3.169	.037	.020	1	1
UCEC	Gab2 →	+0.436	+3.169	.026	.020	1	1
UCEC	p21 →	+0.215	+3.169	.042	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MEK1 by FBXO36 expression — UCEC

Explore this box plot interactively →