FBXO36

Across TCGA pan-cancer cohorts, FBXO36 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FBXO36’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where FBXO36 RNA is repressed in tumor relative to normal tissue. In most cancer types FBXO36 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and KIRC are the cancer types where FBXO36 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBXO36 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.920	<.001	11	view →
THCA	Male	III,IV	−1.081	<.001	10	view →
KIRC	Male	II,III,IV	−0.622	<.001	8	view →
LIHC	Female	All	+0.516	<.001	6	view →
LUSC	All	II,III,IV	−0.554	.008	3	view →
STAD	All	II,III,IV	+0.501	.014	3	view →
CHOL	Male	All	+1.545	<.001	2	view →
COAD	Male	All	+0.229	.011	2	view →
ESCA	Female	All	+0.459	.046	1	view →
BRCA	All	II,III,IV	+0.219	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

FBXO36–KICH

Open the KICH breakdown →