FBXO33

Across TCGA patient cohorts, FBXO33 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO33-associated genes across cancer lineages are EGFR_pY1068, FOXO3a, and ACC1. Each is linked with FBXO33 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO33-to-partner and partner-to-FBXO33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by FBXO33-low versus FBXO33-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO33→partner) and Y-score (partner→FBXO33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.295	-2.584	.011	.011	3	1
UCEC	FOXO3a →	-0.115	-3.292	.015	.010	3	1
UCEC	ACC1 →	+0.366	+2.820	.030	.035	3	1
UCEC	Caspase-8 →	-0.294	-3.432	.012	.005	3	1
UCEC	4E-BP1_pT70 →	+0.114	+2.584	.033	.011	3	1
UCEC	cIAP →	+0.161	+3.179	.012	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by FBXO33 expression — UCEC

Explore this box plot interactively →