FBXO33

Across TCGA pan-cancer cohorts, FBXO33 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated FBXO33 data layer compared with 5 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher FBXO33 RNA is associated with better overall survival. In most high-consensus cancer types, elevated FBXO33 expression acts as an unfavorable survival marker, although some lineages such as LUAD and MESO show a favorable association.

LUAD, MESO, and ACC are the cancer types where FBXO33 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.654	0.472	.002	78	view →
MESO	DFS	Tertile	II,III,IV	0.539	0.270	<.001	74	view →
ACC	OS	Median	All	0.953	0.790	.001	45	view →
KIRC	DFS	Median	All	0.703	0.552	<.001	41	view →
UVM	DFS	Quartile	III,IV	0.170	0.813	.003	38	view →
HNSC	OS	Tertile	III,IV	0.479	0.794	.001	32	view →
UCS	DFS	Tertile	IV	0.932	0.419	.024	24	view →
LIHC	OS	Median	All	0.629	0.779	.007	21	view →
PRAD	DFS	Quartile	All	0.939	0.832	.004	18	view →
LUSC	OS	Quartile	All	0.550	0.358	.003	15	view →
CHOL	DFS	Median	All	0.718	0.109	<.001	15	view →
BLCA	DFS	Quartile	All	0.198	0.574	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

FBXO33–LUAD (OS)

Open the LUAD breakdown →