FBXO33

Across TCGA cell cohorts, FBXO33 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXO33-associated genes across cancer lineages are SCGB1C1, IFNK, and SLCO1C1. Each is linked with FBXO33 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO33-to-partner and partner-to-FBXO33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB1C1 grouped by FBXO33-low versus FBXO33-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO33→partner) and Y-score (partner→FBXO33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SCGB1C1 →	+0.043	+4.078	<.001	.009	3	2
SKIN	IFNK →	+0.085	+4.095	<.001	.009	3	1
LARGE_INTESTINE	SLCO1C1 →	+0.468	+3.772	<.001	.003	3	1
LARGE_INTESTINE	ECE2 →	+0.295	+4.376	<.001	<.001	3	1
LARGE_INTESTINE	COX6A2 →	+0.068	+4.022	<.001	.006	3	1
LARGE_INTESTINE	PHOX2A →	+0.057	+3.906	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

SCGB1C1 by FBXO33 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →