FBXO32

Across TCGA patient cohorts, FBXO32 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO32-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and ERK2. Each is linked with FBXO32 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO32-to-partner and partner-to-FBXO32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by FBXO32-low versus FBXO32-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO32→partner) and Y-score (partner→FBXO32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.120	-3.432	.002	.005	3	1
UCEC	EGFR_pY1068 →	-0.281	-3.700	.005	.001	3	1
UCEC	ERK2 →	+0.178	+2.415	.021	.003	3	1
UCEC	IGFBP2 →	-0.624	-2.321	.017	.034	3	1
UCEC	JNK_pT183_Y185 →	-0.193	-3.807	.004	<.001	3	1
UCEC	JNK2 →	+0.212	+2.415	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

14-3-3_beta by FBXO32 expression — UCEC

Explore this box plot interactively →