FBXO3

Across TCGA pan-cancer cohorts, FBXO3 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of FBXO3’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where FBXO3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types FBXO3 is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

LUAD, LSCC, and COAD are the cancer types where FBXO3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBXO3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	−0.217	<.001	9	view →
LSCC	Male	II,III,IV	−0.218	<.001	7	view →
COAD	Female	III,IV	+0.439	.030	2	view →
OV	All	All	−0.327	.048	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

FBXO3–LUAD

Open the LUAD breakdown →