FBXO3

Across TCGA pan-cancer cohorts, FBXO3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated FBXO3 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher FBXO3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated FBXO3 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

KIRC, LUSC, and BRCA are the cancer types where FBXO3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.763	0.508	<.001	140	view →
LUSC	DFS	Median	III,IV	0.400	0.683	.001	33	view →
BRCA	DFS	Tertile	III,IV	0.946	0.788	.001	25	view →
KICH	DFS	Median	III,IV	0.299	1.000	.004	23	view →
ACC	DFS	Quartile	All	0.154	0.768	<.001	21	view →
SKCM	OS	Tertile	All	0.345	0.229	.013	18	view →
LIHC	OS	Tertile	All	0.710	0.852	.007	10	view →
KIRP	DFS	Tertile	All	0.931	0.649	.015	8	view →
STAD	DFS	Tertile	IV	0.231	0.596	.034	7	view →
BLCA	DFS	Median	All	0.218	0.505	.016	6	view →
THCA	DFS	Median	All	0.878	0.783	.034	4	view →
THYM	DFS	Quartile	III,IV	1.000	0.236	.012	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

FBXO3–KIRC (OS)

Open the KIRC breakdown →