FBXO3

Across TCGA patient cohorts, FBXO3 mutation is significantly associated with the RNA expression of many other genes, with 3,400 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO3-associated genes across cancer lineages are RNY4P16, MIR4663, and RNU1-17P. Each is linked with FBXO3 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXO3-to-partner and partner-to-FBXO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNY4P16 grouped by FBXO3-low versus FBXO3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO3→partner) and Y-score (partner→FBXO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNY4P16 →	+0.652	+6.444	<.001	.001	3	3
LUSC	MIR4663 →	+0.374	+5.337	.001	.006	3	2
CESC	RNU1-17P →	+0.438	+5.103	<.001	.008	3	2
CESC	RPL35AP30 →	+0.137	+5.010	<.001	.009	3	2
CESC	UBE2V1P4 →	+0.181	+5.103	<.001	.008	3	2
SKCM	MIR769 →	+0.260	+3.449	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,400 associations by consensus.

RNY4P16 by FBXO3 expression — BLCA

Explore this box plot interactively →