FBXO3

Across TCGA patient cohorts, FBXO3 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO3-associated genes across cancer lineages are STAT3_pY705, ATM, and c-Met_pY1235. Each is linked with FBXO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO3-to-partner and partner-to-FBXO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by FBXO3-low versus FBXO3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO3→partner) and Y-score (partner→FBXO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.378	-2.000	<.001	.003	3	2
UCEC	ATM →	-0.648	-2.392	<.001	<.001	3	2
UCEC	c-Met_pY1235 →	+0.069	+2.232	.008	.005	3	2
UCEC	EGFR →	-0.123	-2.000	.030	.030	3	1
UCEC	eIF4E →	+0.153	+1.662	.039	.011	3	1
UCEC	A-Raf_pS299 →	-0.160	-2.392	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

STAT3_pY705 by FBXO3 expression — UCEC

Explore this box plot interactively →