FBXO3

Across TCGA cell cohorts, FBXO3 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXO3-associated genes across cancer lineages are GPR6, TBC1D21, and SYCN. Each is linked with FBXO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO3-to-partner and partner-to-FBXO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR6 grouped by FBXO3-low versus FBXO3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO3→partner) and Y-score (partner→FBXO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GPR6 →	+0.005	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
BLOOD_Leukemia	SYCN →	+0.035	+4.539	<.001	.007	3	1
LARGE_INTESTINE	LILRB5 →	+0.039	+3.169	<.001	.006	2	1
BLOOD_Leukemia	MYOCD →	+1.393	+4.108	<.001	.009	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

GPR6 by FBXO3 expression — LARGE_INTESTINE

Explore this box plot interactively →