FBXO3

Across TCGA cell cohorts, FBXO3 mutation is significantly associated with the mutation status of many other genes, with 1,667 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FBXO3-associated genes across cancer lineages are FOLR1, ARHGEF38, and GNAS. Each is linked with FBXO3 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXO3-to-partner and partner-to-FBXO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOLR1 grouped by FBXO3-low versus FBXO3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO3→partner) and Y-score (partner→FBXO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FOLR1 →	+4.215	+3.874	<.001	<.001	1	3
LARGE_INTESTINE	ARHGEF38 →	+4.215	+3.874	<.001	<.001	1	3
BLOOD_Leukemia	GNAS →	+2.582	+3.377	.001	.001	1	2
LARGE_INTESTINE	DZANK1 →	+3.799	+3.329	.005	.005	1	2
LARGE_INTESTINE	ANKRD24 →	+3.215	+3.415	.002	.002	1	2
BLOOD_Leukemia	GANAB →	+2.523	+2.960	.005	.005	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,667 associations by consensus.

FOLR1 by FBXO3 expression — LARGE_INTESTINE

Explore this box plot interactively →