FBXO3-DT

Across TCGA pan-cancer cohorts, FBXO3-DT RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated FBXO3-DT data layer.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher FBXO3-DT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FBXO3-DT expression acts as an unfavorable survival marker, although some lineages such as KIRP and ESCA show a favorable association.

DLBC, LUSC, and ACC are the cancer types where FBXO3-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Tertile	II,III,IV	0.172	0.949	<.001	81	view →
LUSC	OS	Tertile	II,III,IV	0.499	0.810	.008	72	view →
ACC	DFS	Tertile	IV	0.012	0.310	.002	36	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	30	view →
LIHC	OS	Tertile	All	0.652	0.815	.003	30	view →
SKCM	DFS	Tertile	IV	0.049	0.500	.001	27	view →
THCA	OS	Tertile	All	0.676	0.974	.001	27	view →
KIRP	OS	Tertile	All	0.967	0.857	.004	25	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	18	view →
THYM	DFS	Tertile	III,IV	0.214	1.000	.008	18	view →
UCS	OS	Tertile	All	0.185	0.686	.034	18	view →
ESCA	DFS	Quartile	III,IV	0.544	0.249	.026	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

FBXO3-DT–DLBC (OS)

Open the DLBC breakdown →