FBXO3-DT

Across TCGA pan-cancer cohorts, FBXO3-DT RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of FBXO3-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where FBXO3-DT RNA is repressed in tumor relative to normal tissue. In most cancer types FBXO3-DT is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and PRAD are the cancer types where FBXO3-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBXO3-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.247	<.001	6	view →
THCA	Female	All	−0.087	.006	3	view →
PRAD	All	All	−0.089	<.001	2	view →
BRCA	All	III,IV	−0.085	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

FBXO3-DT–KICH

Open the KICH breakdown →