FBXO27

Across TCGA pan-cancer cohorts, FBXO27 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FBXO27 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher FBXO27 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FBXO27 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

GBM, LSCC, and HNSC are the cancer types where FBXO27 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Tertile	All	0.989	0.546	.009	9	view →
LSCC	DFS	Quartile	All	1.000	0.671	.045	2	view →
HNSC	DFS	Median	II,III,IV	0.773	0.523	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

FBXO27–GBM (DFS)

Open the GBM breakdown →