FBXO27

Across TCGA patient cohorts, FBXO27 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO27-associated genes across cancer lineages are p27_pT157, MEK1, and STAT3_pY705. Each is linked with FBXO27 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO27-to-partner and partner-to-FBXO27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT157 grouped by FBXO27-low versus FBXO27-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO27→partner) and Y-score (partner→FBXO27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	p27_pT157 →	+0.227	+2.815	.004	.036	3	1
UCEC	MEK1 →	+0.423	+3.000	.045	.037	3	1
UCEC	STAT3_pY705 →	-0.475	-3.000	.001	.037	3	1
UCEC	Rad50 →	-0.309	-3.000	.027	.037	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

p27_pT157 by FBXO27 expression — COAD

Explore this box plot interactively →