FBXO25

Across TCGA patient cohorts, FBXO25 RNA expression is significantly associated with the mutation status of many other genes, with 10,457 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO25-associated genes across cancer lineages are PEG3, IGF2R, and STAB2. Each is linked with FBXO25 in more than 4 cancer types. Because this analysis shows association rather than direction, both FBXO25-to-partner and partner-to-FBXO25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEG3 grouped by FBXO25-low versus FBXO25-high in UCEC.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO25→partner) and Y-score (partner→FBXO25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PEG3 →	+2.074	+0.345	<.001	<.001	3	5
COAD	IGF2R →	+2.820	+0.374	<.001	.001	3	5
LUSC	STAB2 →	+2.596	+0.329	<.001	.001	3	4
BRCA	TP53 →	-1.134	-0.406	<.001	<.001	3	4
HNSC	TTN →	+0.872	+0.149	<.001	.009	3	4
STAD	HERC2 →	+2.180	+0.375	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,457 associations by consensus.

PEG3 by FBXO25 expression — UCEC

Explore this box plot interactively →