FBXO25

Across TCGA pan-cancer cohorts, FBXO25 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated FBXO25 data layer compared with 4 for mutation status.

The strongest signal is observed in brain lower grade glioma (LGG), where higher FBXO25 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated FBXO25 expression acts as an unfavorable survival marker, although some lineages such as LGG and THYM show a favorable association.

LGG, THYM, and READ are the cancer types where FBXO25 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.816	0.648	<.001	40	view →
THYM	DFS	Median	All	0.952	0.783	.001	34	view →
READ	OS	Median	II,III,IV	1.000	0.836	.003	31	view →
BLCA	OS	Quartile	All	0.326	0.711	.008	29	view →
KIRC	OS	Median	All	0.898	0.849	.003	28	view →
STAD	DFS	Median	IV	0.190	0.652	.006	24	view →
DLBC	DFS	Quartile	All	0.878	0.363	.003	23	view →
HNSC	DFS	Quartile	IV	0.731	0.533	.010	22	view →
SKCM	DFS	Median	II,III,IV	0.640	0.496	<.001	20	view →
PRAD	DFS	Median	All	0.924	0.843	.002	18	view →
CESC	OS	Tertile	All	0.680	0.462	.011	14	view →
ACC	OS	Median	IV	0.908	0.475	.003	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

FBXO25–LGG (DFS)

Open the LGG breakdown →