FBXO25

Across TCGA patient cohorts, FBXO25 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO25-associated genes across cancer lineages are FOXO3a_pS318_S321, JNK_pT183_Y185, and Ku80. Each is linked with FBXO25 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO25-to-partner and partner-to-FBXO25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by FBXO25-low versus FBXO25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO25→partner) and Y-score (partner→FBXO25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.121	-3.160	.045	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.266	-2.446	.001	.020	3	1
UCEC	Ku80 →	+0.287	+2.179	.011	.034	3	1
UCEC	MEK1 →	+0.426	+3.321	.015	.010	3	1
UCEC	Myosin-IIa →	+0.220	+2.821	.014	.034	3	1
UCEC	PCNA →	+0.340	+2.459	.001	.020	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

FOXO3a_pS318_S321 by FBXO25 expression — UCEC

Explore this box plot interactively →