FBXO25

Across TCGA cell cohorts, FBXO25 mutation is significantly associated with the mutation status of many other genes, with 317 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FBXO25-associated genes across cancer lineages are LAMB3, INSR, and ZNF746. Each is linked with FBXO25 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO25-to-partner and partner-to-FBXO25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LAMB3 grouped by FBXO25-low versus FBXO25-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO25→partner) and Y-score (partner→FBXO25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	LAMB3 →	+5.115	+5.115	.005	.005	1	2
BLOOD_Lymphoma	INSR →	+4.014	+4.969	.008	.008	1	2
BLOOD_Lymphoma	ZNF746 →	+4.429	+5.247	.005	.005	1	2
BLOOD_Lymphoma	ZFP28 →	+5.014	+5.584	.003	.003	1	2
STOMACH	ADGRG4 →	+3.584	+3.584	.006	.006	1	2
STOMACH	BRF1 →	+5.000	+5.000	<.001	<.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 317 associations by consensus.

LAMB3 by FBXO25 expression — PANCREAS

Explore this box plot interactively →