FBXO22

Across TCGA cell cohorts, FBXO22 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FBXO22-associated genes across cancer lineages are TAAR2, SPINK14, and LGI1. Each is linked with FBXO22 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO22-to-partner and partner-to-FBXO22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAAR2 grouped by FBXO22-low versus FBXO22-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO22→partner) and Y-score (partner→FBXO22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TAAR2 →	+0.020	+5.285	<.001	.003	3	1
STOMACH	SPINK14 →	+0.433	+5.285	<.001	.003	3	1
BLOOD_Leukemia	LGI1 →	+0.096	+4.539	<.001	.007	3	1
BLOOD_Leukemia	C20orf85 →	+0.036	+4.969	<.001	.003	3	1
BLOOD_Leukemia	IL22 →	+0.037	+5.569	<.001	.001	3	1
BLOOD_Leukemia	ART1 →	+0.022	+4.705	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

TAAR2 by FBXO22 expression — STOMACH

Explore this box plot interactively →