FBXO10

Across TCGA patient cohorts, FBXO10 protein abundance is significantly associated with the protein abundance of many other proteins, with 3,909 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FBXO10-associated proteins across cancer lineages are UBA3_S377, C1QTNF3, and CTTNBP2NL_S549. Each is linked with FBXO10 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO10-to-partner and partner-to-FBXO10 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FBXO10 versus UBA3_S377 in GBM, with a Pearson correlation of -0.47.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO10→partner) and Y-score (partner→FBXO10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	UBA3_S377 →	-0.676	-0.887	<.001	<.001	3	2
BRCA	C1QTNF3 →	+1.281	+1.155	<.001	.003	3	2
BRCA	CTTNBP2NL_S549 →	+1.532	+1.190	<.001	.001	3	2
GBM	KIAA0513_S73 →	-1.012	-0.543	<.001	<.001	3	2
LSCC	BRI3BP_S248 →	-2.139	-1.132	<.001	.003	3	2
UCEC	PRTN3 →	+1.672	+0.950	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,909 associations by consensus.

FBXO10 vs UBA3_S377 — GBM

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