FBXO10

Across TCGA patient cohorts, FBXO10 mutation is significantly associated with the RNA expression of many other genes, with 4,812 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO10-associated genes across cancer lineages are RNF19B, VSTM2L, and LDHA. Each is linked with FBXO10 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXO10-to-partner and partner-to-FBXO10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNF19B grouped by FBXO10-low versus FBXO10-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO10→partner) and Y-score (partner→FBXO10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNF19B →	+0.482	+2.920	.001	.001	3	3
UCEC	VSTM2L →	-0.649	-2.039	.004	<.001	3	3
UCEC	LDHA →	+0.514	+1.616	.001	.002	3	3
COAD	PTP4A3 →	-1.189	-4.000	<.001	<.001	3	3
UCEC	ATL3 →	+0.488	+2.137	<.001	<.001	3	3
UCEC	CCNDBP1 →	+0.401	+2.385	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,812 associations by consensus.

RNF19B by FBXO10 expression — COAD

Explore this box plot interactively →