FBXO10

Across TCGA patient cohorts, FBXO10 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO10-associated genes across cancer lineages are ATM, EGFR_pY1068, and MEK1. Each is linked with FBXO10 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXO10-to-partner and partner-to-FBXO10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FBXO10-low versus FBXO10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO10→partner) and Y-score (partner→FBXO10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.385	-2.102	.007	.016	3	3
UCEC	EGFR_pY1068 →	-0.267	-1.836	<.001	.001	3	2
UCEC	MEK1 →	+0.389	+2.415	<.001	.002	3	2
UCEC	NF2 →	+0.190	+1.807	.005	.024	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.301	-1.124	.034	.041	3	2
UCEC	PCNA →	+0.155	+1.137	.022	.041	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

ATM by FBXO10 expression — UCEC

Explore this box plot interactively →