FBXL8

Across TCGA pan-cancer cohorts, FBXL8 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FBXL8 data layer compared with 19 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher FBXL8 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated FBXL8 expression acts as an unfavorable survival marker.

BLCA, SKCM, and BRCA are the cancer types where FBXL8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	All	0.131	0.629	<.001	36	view →
SKCM	DFS	Median	All	0.022	0.739	<.001	36	view →
BRCA	OS	Median	All	0.136	0.578	.010	16	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

FBXL8–BLCA (DFS)

Open the BLCA breakdown →