FBXL8

Across TCGA pan-cancer cohorts, FBXL8 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FBXL8 data layer compared with 19 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher FBXL8 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FBXL8 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

LUAD, LSCC, and GBM are the cancer types where FBXL8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.497	0.796	.015	12	view →
LSCC	DFS	Tertile	All	0.882	0.971	.007	12	view →
GBM	OS	Quartile	All	0.284	0.507	.030	5	view →
PDAC	OS	Median	III,IV	0.769	0.167	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

FBXL8–LUAD (OS)

Open the LUAD breakdown →