FBXL8

Across TCGA patient cohorts, FBXL8 protein abundance is significantly associated with the RNA expression of many other genes, with 16,380 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FBXL8-associated genes across cancer lineages are CDCA8, MYBL2, and CDCA3. Each is linked with FBXL8 in more than 5 cancer types. Because this analysis shows association rather than direction, both FBXL8-to-partner and partner-to-FBXL8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FBXL8 versus CDCA8 in BRCA, with a Pearson correlation of -0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL8→partner) and Y-score (partner→FBXL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDCA8 →	-1.256	-0.535	<.001	<.001	3	6
BRCA	MYBL2 →	-1.222	-0.384	<.001	<.001	3	5
BRCA	CDCA3 →	-0.791	-0.308	<.001	<.001	3	5
BRCA	CENPA →	-1.405	-0.620	<.001	<.001	3	5
BRCA	KIF14 →	-0.787	-0.345	<.001	<.001	3	5
LSCC	HROB →	-0.710	-0.249	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,380 associations by consensus.

FBXL8 vs CDCA8 — BRCA

Explore this scatter interactively →