FBXL8

Across TCGA cell cohorts, FBXL8 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXL8-associated genes across cancer lineages are GHRHR, MAGEB4, and TKTL2. Each is linked with FBXL8 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL8-to-partner and partner-to-FBXL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRHR grouped by FBXL8-low versus FBXL8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL8→partner) and Y-score (partner→FBXL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GHRHR →	+0.043	+2.791	.005	.005	3	1
LARGE_INTESTINE	MAGEB4 →	+0.012	+3.678	<.001	.001	3	1
LARGE_INTESTINE	TKTL2 →	+0.040	+3.509	<.001	.001	3	1
LARGE_INTESTINE	TFDP3 →	+0.015	+2.933	.004	.003	3	1
LARGE_INTESTINE	MINAR2 →	+0.030	+2.882	.001	.005	3	1
LARGE_INTESTINE	DAZ2 →	+0.127	+3.678	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

GHRHR by FBXL8 expression — LARGE_INTESTINE

Explore this box plot interactively →