FBXL5

Across TCGA patient cohorts, FBXL5 mutation is significantly associated with the RNA expression of many other genes, with 3,582 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXL5-associated genes across cancer lineages are TTTY19, OR10AK1P, and RAET1M. Each is linked with FBXL5 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXL5-to-partner and partner-to-FBXL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTTY19 grouped by FBXL5-low versus FBXL5-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL5→partner) and Y-score (partner→FBXL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	TTTY19 →	+0.273	+5.274	.003	.006	3	3
BLCA	OR10AK1P →	+0.198	+5.033	<.001	.003	3	3
GBM	RAET1M →	+0.107	+5.857	<.001	.002	3	2
GBM	SLC7A15P →	+0.061	+5.352	<.001	.005	3	2
GBM	RN7SKP24 →	+0.261	+6.614	<.001	<.001	3	2
SKCM	KRTAP22-1 →	+0.157	+5.900	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,582 associations by consensus.

TTTY19 by FBXL5 expression — STAD

Explore this box plot interactively →