FBXL5

Across TCGA cell cohorts, FBXL5 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXL5-associated genes across cancer lineages are RETNLB, SYCN, and MAGEB4. Each is linked with FBXL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL5-to-partner and partner-to-FBXL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RETNLB grouped by FBXL5-low versus FBXL5-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL5→partner) and Y-score (partner→FBXL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RETNLB →	+0.069	+5.169	<.001	.005	3	1
BREAST	SYCN →	+0.064	+5.169	<.001	.005	3	1
LARGE_INTESTINE	MAGEB4 →	+0.016	+4.415	<.001	<.001	3	1
LARGE_INTESTINE	UGT2B4 →	+1.007	+3.556	<.001	.007	3	1
LARGE_INTESTINE	BPY2 →	+0.015	+4.022	<.001	.006	3	1
LARGE_INTESTINE	BPY2B →	+0.015	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

RETNLB by FBXL5 expression — BREAST

Explore this box plot interactively →