FBXL3

Across TCGA pan-cancer cohorts, FBXL3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FBXL3 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FBXL3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated FBXL3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where FBXL3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.948	0.728	.013	10	view →
LUAD	DFS	Quartile	All	1.000	0.431	.016	8	view →
CCRCC	DFS	Tertile	III,IV	0.781	0.254	.013	5	view →
PDAC	OS	Median	II,III,IV	0.416	0.683	.032	4	view →
UCEC	OS	Tertile	III,IV	1.000	0.689	.040	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FBXL3–HNSC (OS)

Open the HNSC breakdown →