FBXL3

Across TCGA pan-cancer cohorts, FBXL3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FBXL3’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where FBXL3 RNA is repressed in tumor relative to normal tissue. In most cancer types FBXL3 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LUAD are the cancer types where FBXL3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBXL3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.380	<.001	11	view →
KICH	Female	All	−1.500	<.001	10	view →
LUAD	Female	III,IV	−1.116	<.001	9	view →
KIRP	Male	All	−0.830	<.001	9	view →
LUSC	Female	All	−0.935	<.001	8	view →
UCEC	All	All	−1.780	<.001	6	view →
BRCA	All	All	−0.369	<.001	6	view →
COAD	Female	All	−0.701	.001	4	view →
READ	All	All	−0.851	.003	2	view →
KIRC	Male	III,IV	−0.328	.034	2	view →
BLCA	Male	IV	−0.502	.010	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

FBXL3–THCA

Open the THCA breakdown →