FBXL3

Across TCGA patient cohorts, FBXL3 mutation is significantly associated with the RNA expression of many other genes, with 3,540 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXL3-associated genes across cancer lineages are MTND5P27, OR2W5, and TUBB4BP5. Each is linked with FBXL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL3-to-partner and partner-to-FBXL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND5P27 grouped by FBXL3-low versus FBXL3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL3→partner) and Y-score (partner→FBXL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MTND5P27 →	+0.156	+5.917	<.001	.001	3	2
BLCA	OR2W5 →	+0.091	+5.038	.004	.009	3	2
SKCM	TUBB4BP5 →	+0.079	+7.816	<.001	.008	3	2
UCEC	RNA5SP412 →	+0.590	+2.339	<.001	<.001	3	2
UCEC	PRAMEF13 →	+0.020	+2.868	<.001	.002	3	2
UCEC	RNA5SP410 →	+0.782	+2.374	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,540 associations by consensus.

MTND5P27 by FBXL3 expression — COAD

Explore this box plot interactively →