FBXL3

Across TCGA cell cohorts, FBXL3 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FBXL3-associated genes across cancer lineages are MAGEB4, GML, and CFC1. Each is linked with FBXL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL3-to-partner and partner-to-FBXL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by FBXL3-low versus FBXL3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL3→partner) and Y-score (partner→FBXL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.012	+5.415	.009	.004	3	1
BLOOD_Leukemia	GML →	+0.107	+4.152	<.001	.009	3	1
BLOOD_Leukemia	CFC1 →	+0.016	+4.539	<.001	.007	3	1
BLOOD_Leukemia	GPR26 →	+0.057	+4.539	<.001	.007	3	1
BLOOD_Leukemia	CYP2C19 →	+0.022	+4.152	<.001	.009	3	1
BLOOD_Leukemia	TMPRSS7 →	+0.067	+4.276	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MAGEB4 by FBXL3 expression — LARGE_INTESTINE

Explore this box plot interactively →