Across TCGA patient cohorts, FBXL22 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXL22-associated genes across cancer lineages are RN7SL196P, RN7SKP157, and MIR6859-2. Each is linked with FBXL22 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL22-to-partner and partner-to-FBXL22 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL22→partner) and Y-score (partner→FBXL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL196P →	+0.159	+7.731	<.001	.009	3	1
BRCA	RN7SKP157 →	+0.163	+8.055	<.001	.007	3	1
UCEC	MIR6859-2 →	+0.479	+3.105	<.001	.005	3	1
UCEC	RNA5SP411 →	+1.708	+3.130	<.001	.003	3	1
UCEC	RNA5SP412 →	+0.646	+2.967	.006	.007	3	1
UCEC	IL21 →	+0.236	+2.763	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration

FBXL22 survival (RNA) · tumor vs normal (RNA) · all FBXL22 data types