Across TCGA pan-cancer cohorts, FBXL22 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated FBXL22 data layer compared with 1 for mutation status.
The strongest signal is observed in esophageal carcinoma (ESCA), where higher FBXL22 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated FBXL22 expression acts as an unfavorable survival marker, although some lineages such as ESCA and KIRC show a favorable association.
ESCA, KIRC, and UCS are the cancer types where FBXL22 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.