FBXL21P

Across TCGA patient cohorts, FBXL21P mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXL21P-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and EGFR_pY1068. Each is linked with FBXL21P in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL21P-to-partner and partner-to-FBXL21P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by FBXL21P-low versus FBXL21P-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL21P→partner) and Y-score (partner→FBXL21P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.673	+1.926	.001	.008	3	2
UCEC	14-3-3_beta →	-0.099	-2.558	.005	.010	3	1
UCEC	EGFR_pY1068 →	-0.280	-2.700	.001	.006	3	1
UCEC	A-Raf_pS299 →	-0.097	-1.700	.021	.042	3	1
UCEC	ERK2 →	+0.135	+1.362	.046	.037	3	1
UCEC	JNK2 →	+0.235	+2.874	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Caspase-7-cleavedD198 by FBXL21P expression — UCEC

Explore this box plot interactively →