FBXL21P

Across TCGA pan-cancer cohorts, FBXL21P RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated FBXL21P data layer compared with 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FBXL21P RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FBXL21P expression acts as an unfavorable survival marker, although some lineages such as KIRP and THCA show a favorable association.

UCEC, KIRP, and CHOL are the cancer types where FBXL21P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.433	0.728	<.001	100	view →
KIRP	DFS	Quartile	III,IV	0.724	0.268	.009	44	view →
CHOL	OS	Tertile	III,IV	0.162	0.915	.010	33	view →
THCA	DFS	Tertile	II,III,IV	0.890	0.254	.003	29	view →
LUAD	DFS	Quartile	All	0.209	0.376	.002	25	view →
UVM	DFS	Median	All	0.499	0.849	.004	18	view →
LGG	OS	Tertile	All	0.529	0.386	.009	18	view →
ACC	OS	Tertile	IV	0.783	0.263	.019	18	view →
PRAD	DFS	Tertile	All	0.935	0.834	.002	18	view →
PCPG	DFS	Tertile	All	0.862	0.956	.008	12	view →
PAAD	DFS	Quartile	All	0.454	0.222	.011	11	view →
STAD	DFS	Quartile	IV	0.824	0.230	.021	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

FBXL21P–UCEC (DFS)

Open the UCEC breakdown →