FBXL2

Across TCGA patient cohorts, FBXL2 protein abundance is significantly associated with the RNA expression of many other genes, with 2,370 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FBXL2-associated genes across cancer lineages are DEPDC7, ALDH1A1, and C16orf54. Each is linked with FBXL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXL2-to-partner and partner-to-FBXL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FBXL2 versus DEPDC7 in OV, with a Pearson correlation of -0.70.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL2→partner) and Y-score (partner→FBXL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DEPDC7 →	-1.694	-0.319	.005	.006	3	2
OV	ALDH1A1 →	-2.305	-0.475	.008	.003	3	2
OV	C16orf54 →	-1.251	-0.373	.008	.007	3	2
LSCC	SPATA41 →	-0.557	-0.506	<.001	<.001	3	2
UCEC	LINC01124 →	-1.571	-0.608	.003	.003	3	2
OV	RPL32P34 →	+0.704	+0.363	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,370 associations by consensus.

FBXL2 vs DEPDC7 — OV

Explore this scatter interactively →