FBXL18

Across TCGA pan-cancer cohorts, FBXL18 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated FBXL18 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher FBXL18 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FBXL18 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

LSCC, LUAD, and UCEC are the cancer types where FBXL18 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	All	0.641	0.932	.002	20	view →
LUAD	DFS	Tertile	All	0.622	1.000	.003	16	view →
UCEC	DFS	Median	All	0.957	0.846	.015	8	view →
PDAC	DFS	Tertile	IV	0.203	0.752	.024	5	view →
CCRCC	OS	Median	II,III,IV	0.752	0.908	.047	1	view →
GBM	DFS	Quartile	All	0.793	0.630	.048	1	view →
HNSC	OS	Quartile	II,III,IV	1.000	0.925	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

FBXL18–LSCC (OS)

Open the LSCC breakdown →