FBXL17

Across TCGA patient cohorts, FBXL17 protein abundance is significantly associated with the RNA expression of many other genes, with 9,285 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible FBXL17-associated genes across cancer lineages are APC, REEP5, and COMMD10. Each is linked with FBXL17 in more than 4 cancer types. Because this analysis shows association rather than direction, both FBXL17-to-partner and partner-to-FBXL17 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FBXL17 versus APC in BRCA, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL17→partner) and Y-score (partner→FBXL17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	APC →	+0.649	+0.337	<.001	.001	3	5
BRCA	REEP5 →	+0.785	+0.409	<.001	<.001	3	4
BRCA	COMMD10 →	+0.568	+0.319	<.001	<.001	3	4
CCRCC	PHAX →	+0.291	+0.230	<.001	.002	3	4
BRCA	DMXL1 →	+0.518	+0.268	<.001	<.001	3	4
BRCA	SLC22A4 →	+0.562	+0.240	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,285 associations by consensus.

FBXL17 vs APC — BRCA

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