FBXL17

Across TCGA cell cohorts, FBXL17 mutation is significantly associated with the RNA expression of many other genes, with 241 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXL17-associated genes across cancer lineages are FSHB, PDE6H, and CCDC105. Each is linked with FBXL17 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL17-to-partner and partner-to-FBXL17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FSHB grouped by FBXL17-low versus FBXL17-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL17→partner) and Y-score (partner→FBXL17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FSHB →	+0.012	+5.247	<.001	.001	3	1
LUNG_NSCLC_LUAD	PDE6H →	+0.085	+3.951	.007	.005	3	1
LUNG_NSCLC_LUAD	CCDC105 →	+0.003	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR2W1 →	+0.025	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	PADI6 →	+0.056	+3.866	<.001	.006	3	1
BLOOD_Leukemia	OR4K2 →	+0.031	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 241 associations by consensus.

FSHB by FBXL17 expression — BLOOD_Lymphoma

Explore this box plot interactively →