FBXL17

Across TCGA cell cohorts, FBXL17 mutation is significantly associated with the mutation status of many other genes, with 2,050 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXL17-associated genes across cancer lineages are PHF21A, MIB1, and SGK3. Each is linked with FBXL17 in more than 3 cancer types. Because this analysis shows association rather than direction, both FBXL17-to-partner and partner-to-FBXL17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHF21A grouped by FBXL17-low versus FBXL17-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL17→partner) and Y-score (partner→FBXL17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PHF21A →	+4.247	+4.554	.001	.001	1	4
BLOOD_Lymphoma	MIB1 →	+4.247	+4.554	.001	.001	1	3
BLOOD_Lymphoma	SGK3 →	+5.247	+4.429	.005	.005	1	3
BLOOD_Lymphoma	ARHGEF6 →	+5.247	+4.429	.005	.005	1	3
BLOOD_Leukemia	DCAF1 →	+4.894	+4.894	.004	.004	1	3
LUNG_NSCLC_LUAD	CELSR2 →	+2.548	+3.469	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,050 associations by consensus.

PHF21A by FBXL17 expression — BLOOD_Lymphoma

Explore this box plot interactively →