FBXL15

Across TCGA patient cohorts, FBXL15 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. CESC shows the largest number of these associations.

The most reproducible FBXL15-associated genes across cancer lineages are NPBWR2, DAOA, and RNA5SP432. Each is linked with FBXL15 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL15-to-partner and partner-to-FBXL15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPBWR2 grouped by FBXL15-low versus FBXL15-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL15→partner) and Y-score (partner→FBXL15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	NPBWR2 →	+0.041	+5.595	<.001	<.001	3	1
CESC	DAOA →	+0.033	+4.760	<.001	.003	3	1
CESC	RNA5SP432 →	+0.255	+4.539	.001	.008	3	1
CESC	RNA5SP355 →	+0.257	+5.569	<.001	.002	3	1
CESC	RNU6-359P →	+0.310	+5.837	<.001	.001	3	1
CESC	RNU6-14P →	+0.325	+4.669	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

NPBWR2 by FBXL15 expression — CESC

Explore this box plot interactively →