FBXL15

Across TCGA pan-cancer cohorts, FBXL15 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated FBXL15 data layer compared with 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher FBXL15 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FBXL15 expression acts as an unfavorable survival marker, although some lineages such as MESO and LGG show a favorable association.

ACC, MESO, and COAD are the cancer types where FBXL15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.220	0.692	<.001	87	view →
MESO	OS	Quartile	III,IV	0.663	0.368	.006	65	view →
COAD	DFS	Median	II,III,IV	0.591	0.772	.007	36	view →
UCS	DFS	Tertile	III,IV	0.195	0.452	.009	36	view →
LGG	OS	Median	All	0.942	0.847	<.001	34	view →
KIRP	DFS	Tertile	III,IV	0.818	0.274	.008	30	view →
PAAD	OS	Median	All	0.514	0.258	.002	30	view →
UVM	DFS	Quartile	All	0.832	0.324	.001	23	view →
SKCM	OS	Median	All	0.924	0.815	.015	20	view →
SARC	DFS	Tertile	All	0.680	0.501	.001	20	view →
KICH	OS	Median	III,IV	0.347	0.942	.001	20	view →
BLCA	OS	Median	All	0.776	0.657	.004	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

FBXL15–ACC (DFS)

Open the ACC breakdown →