FBXL14

Across TCGA patient cohorts, FBXL14 mutation is significantly associated with the RNA expression of many other genes, with 242 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXL14-associated genes across cancer lineages are MIR7702, RNA5SP389, and RNA5SP161. Each is linked with FBXL14 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL14-to-partner and partner-to-FBXL14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR7702 grouped by FBXL14-low versus FBXL14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL14→partner) and Y-score (partner→FBXL14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR7702 →	+0.284	+4.601	<.001	.003	3	2
UCEC	RNA5SP389 →	+0.880	+2.861	<.001	.004	3	2
UCEC	RNA5SP161 →	+1.507	+2.621	<.001	.001	3	2
UCEC	MIR3928 →	+0.449	+2.631	<.001	.007	3	2
UCEC	RN7SL237P →	+0.425	+3.174	<.001	<.001	3	2
BRCA	RN7SL787P →	+0.214	+5.148	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 242 associations by consensus.

MIR7702 by FBXL14 expression — UCEC

Explore this box plot interactively →