FBXL13

Across TCGA patient cohorts, FBXL13 mutation is significantly associated with the RNA expression of many other genes, with 3,501 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXL13-associated genes across cancer lineages are GINS3, GLRX5, and GAS2L1. Each is linked with FBXL13 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXL13-to-partner and partner-to-FBXL13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GINS3 grouped by FBXL13-low versus FBXL13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL13→partner) and Y-score (partner→FBXL13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GINS3 →	+0.376	+2.080	.003	<.001	3	3
SKCM	GLRX5 →	+0.371	+2.140	<.001	.009	3	3
UCEC	GAS2L1 →	+0.545	+2.058	<.001	<.001	3	3
UCEC	UBE2L3 →	+0.292	+3.095	.001	<.001	3	3
UCEC	GTF2E2 →	+0.405	+3.016	<.001	<.001	3	3
UCEC	DHFR →	+0.624	+2.917	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,501 associations by consensus.

GINS3 by FBXL13 expression — UCEC

Explore this box plot interactively →