FBXL13

Across TCGA pan-cancer cohorts, FBXL13 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of FBXL13’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where FBXL13 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FBXL13 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, LIHC, and KICH are the cancer types where FBXL13 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBXL13 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+0.307	<.001	7	view →
LIHC	All	II,III,IV	+0.100	<.001	7	view →
KICH	Female	II,III,IV	−0.832	<.001	6	view →
HNSC	Male	All	+0.453	.003	6	view →
CHOL	Male	All	+0.896	<.001	5	view →
KIRP	All	IV	+0.547	.001	5	view →
THCA	All	All	−0.209	.004	5	view →
READ	All	All	+0.316	.005	4	view →
BRCA	All	II,III,IV	+0.192	.033	4	view →
UCEC	All	All	−0.558	.011	2	view →
KIRC	All	All	+0.140	.004	2	view →
ESCA	All	All	−1.080	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

FBXL13–COAD

Open the COAD breakdown →