FBXL13

Across TCGA patient cohorts, FBXL13 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXL13-associated genes across cancer lineages are 4E-BP1, 14-3-3_beta, and EGFR_pY1068. Each is linked with FBXL13 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXL13-to-partner and partner-to-FBXL13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by FBXL13-low versus FBXL13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL13→partner) and Y-score (partner→FBXL13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.325	+3.700	<.001	.001	3	3
UCEC	14-3-3_beta →	-0.102	-3.673	.002	.001	3	2
UCEC	EGFR_pY1068 →	-0.214	-1.247	.012	.045	3	2
UCEC	ERK2 →	+0.162	+2.000	.013	.029	3	2
SKCM	Fibronectin →	-0.382	-1.807	.038	.026	3	2
UCEC	MEK1 →	+0.521	+2.523	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

4E-BP1 by FBXL13 expression — UCEC

Explore this box plot interactively →